Cloning, sequencing and analysis of the structural gene and regulatory region of the Pseudomonas aeruginosa chromosomal ampC beta-lactamase.

نویسندگان

  • J M Lodge
  • S D Minchin
  • L J Piddock
  • S J Busby
چکیده

The chromosomal gene from Pseudomonas aeruginosa encoding beta-lactamase has been cloned, and the sequence determined and compared with corresponding sequences of beta-lactamases from members of the enterobacteriaceae. Upstream of the beta-lactamase gene is an open reading frame which we postulate encodes a regulatory protein, AmpR. We identified a helix-turn-helix region in AmpR and a putative AmpR-binding site.

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عنوان ژورنال:
  • The Biochemical journal

دوره 272 3  شماره 

صفحات  -

تاریخ انتشار 1990